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Pascale Guiton
82 quotes
“The main question of my research program is ‘how does Toxoplasma initiate infection in a new host.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“Part of that is asking ‘what are the molecular mechanisms that the parasite uses to interact with the gastrointestinal tract.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“Toxoplasma can infect orally using two forms, the product of sexual reproduction (the oocyst) that eventually sporulate to produce infectious sporozoites.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I am focusing on bradyzoites because sporozoites are highly infectious.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“With bradyzoites, we can look at them in vitro and in mice and they can be easily deactivated.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“We are tackling this main question from several different angles.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“By trying to identify novel virulence determinants that are required specifically for that first stage of infection.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“We want to understand how Toxoplasma goes from a metabolically fast form (tachyzoite, during the acute phase of infection) where it divides rapidly, to a ‘slow’ form (bradyzoite) that divides slowly and is present during chronic infection.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“During this lifecycle, Toxoplasma also undergoes transcriptional changes.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I am also looking at the transcriptional regulation in the parasite and how this affects its metabolism and virulence.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I am collaborating with Professor Scott Roy at San Francisco State, an evolutionary biologist, who is interested in alternative splicing, and he is trying to find unique splicing features of Toxoplasma.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“Another feature of Toxoplasma is the presence of specialized secretory organelles (micronemes, rhoptries and dense granules) found in the apical complex.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“How proteins are trafficked to these organelles is not known, and is something we also hope to uncover.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“We have become interested in understanding the interactions of Toxoplasma with mucus.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“When you ingest Toxoplasma, it has to get through the microbiota, cross the mucous layer, get to the epithelium, cross the epithelium, find its way into the blood.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I never really paused and thought about the impact of mucus on that initial infection until I taught immunology.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I'm interested in looking at the interaction of Toxoplasma with goblet cells.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“We just started this project, which I am very excited about.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I am not very focused and have lots of questions, but I now have teams of undergraduate students working on each of these questions.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“Being at an undergraduate institution, I don't see my science as ‘I need to get data.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I need to publish’ but more as an extension of my teaching.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“In a way the techniques we use are a bit more basic and the students need to learn how to perform them.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“If we need to make some knockout lines, I have to teach them about bacterial growth, aseptic technique, PCR, gel electrophoresis, CRISPR-Cas9.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I enjoy that, and it's about reinforcing the students' skills and getting the data is almost a result of the students learning those things.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“There are obviously risks with this approach, and the progress can be slow well it is slow.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I find teaching science and how to do it so rewarding that this is my primary focus.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“My approach to effective teaching and learning is akin to manoeuvring a railway handcar whereby both learner and teacher work as partners in an environment conducive to learning.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I strongly believe that with the active participation of both individuals.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“My primary objective is to fully engage my students so that they can acquire these values and skills that transcend degree requirements.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“They are lifelong proficiencies applicable to other aspects of their lives.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“I always say if I had to do it all over again, I would be a marine microbiologist.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source
“It's fascinating how we or rather I know so little about microorganisms in the oceans or their interactions with sea creatures.”
Pascale Guiton wikiquote, CC BY-SA 4.0 source