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Denis Noble
26 quotes
“[T]he music of life has no conductor.”
Denis Noble (born 1936) first seen 2012 wikiquote, CC BY-SA 4.0 source
Recorded in: OBC | The Music of Life (2012) Out of the Box Conference, Maribor Slavinia, Out of the box Seminar channel, YouTube.
“The Principle of Biological Relativity... simply states that there is no privileged level of causation in biological systems.”
Denis Noble (born 1936) first seen 2017 wikiquote, CC BY-SA 4.0 source
Recorded in: Denis Noble on the impact of computational biology on evolutionary biology (Nov 9, 2017) voicesfromoxfordUK channel, YouTube.
“Every time a is needed, the appropriate chemical 'code' is 'read off' the ; this gives the pattern of chemical elements that will make that what it is. Our genes encode the sequences of 100 000 or so proteins that make up the human body.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“A living cell is a continuous action-packed drama. ...Complex chains of molecular interaction happen again and again. We call them 'pathways'... And proteins form the backbone of all these biochemical pathways.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“The DNA causes the proteins, the proteins cause the cells, and so on. ...[T]he inside story, is that the information coded in the genes is being expressed. In biologist-speak, the is 'created by' the . The story is seductive.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[W]hat does DNA do? As biological molecules go, not very much.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“The real players in the action of life are the proteins. ...DNA is in comparison rather passive.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“DNA does nothing outside the context of a cell containing these protein systems, just as a CD can do nothing without a CD reader. So we have the paradox that proteins are required for the machinery to read the code to produce the proteins.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“In higher animals, the bits of DNA code that we lump together and call... a 'gene' are... broken up into segments... called 's'... separated by non-coding stretches of DNA, called 's'. The exon codes can be combined in various orders to produce a full protein code.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[I]f a gene consists of three exons, a, b, and c, it could be read as a, b, c, ab, bc, ac, abc, and perhaps... as cba, ca, ba, each... code for a different protein. At present we do not know the rules...”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[T]here is no one-to-one correspondence between genes and biological functions. Strictly... to speak of a 'gene for x' is always incorrect.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[T]he book of life is life itself. It cannot be reduced to just one of its databases. ...[T]he genome is only one of its databases. Function... depends also on... properties... not specified by genes.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“In the Anglo-Saxon world the debate has been dominated by arguments between the gene-centered views of people like Richard Dawkins... and the multi-level selection views of people like Stephen Jay Gould... The gene-centered view... is a metaphorical polemic: the invention of a colourful metaphor to interpret scientific discovery. It is not a straightforward empirical scientific hypothesis.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[L]iving organisms are open systems. ...All the molecules, organs and systems dance to the tune of the organism and its social context. Those molecules include the sequences of DNA we now call s.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“If you already know a lot of science, you may need to relearn what you thought you knew. Because... the twentieth-century biology went up the wrong street in the interpretation and presentation of its many impressive discoveries.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[S]ome very influential twentieth-century biologists presented a simplistic gene-centered view...”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[T]here are no genes 'for' anything. ...Genes are used. They are not active causes.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[T]here is no complete programme in our DNA. Programmes... are distributed across scales in the organism.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[T]here is no privileged level of causation, which is the central statement of the theory of Biological Relativity.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[W]e are far from certain what a gene is... many of the confusions and misrepresentations of biology arise from mixing up different definitions of genes and genetics.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[I]f genes dance, they have been doing so for... most of the period of the Earth's existence... about 4.5 billion years.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[E]ven in the most mathematical areas of science, and biology is rapidly becoming one of those, it is usually possible to explain the concepts in common language, once they have been distilled down from the abstract world of equations.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[L]ike the Bellman in The Hunting of the Snark... 'what I tell you three times is true'. I have deliberately included a certain amount of repetition... usually by expressing the same concept from a different angle or in a different context.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[T]he book begins with the fundamentals of physics and cosmology, yet ends with the fundamentals of biology and the limits to our knowledge. ...[T]here are many links between these various threads.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“[T]he general principle of relativity informs the whole book.”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source
“Proteins are produced in tiny factories inside the cells... Biologists call them ribosomes. ...A DNA sequence that corresponds to the relevant protein sequence is copied onto another molecule... called a 'messenger', which transmits a form of the sequence to the ribosomes. The messenger molecules, called ... are another kind of sequence. The DNA sequences are... a kind of template... sequence of s... transcribed to produce the message... translated into an amino-acid sequence when the protein is made. (s are the units of which protein is made, just as nucleotides are the units of which DNA is composed).”
Denis Noble (born 1936) wikiquote, CC BY-SA 4.0 source